Sacrificial Cobalt−Carbon Bond Homolysis in Coenzyme B(12) as a Cofactor Conservation Strategy

A sophisticated intracellular trafficking pathway in humans is used to tailor vitamin B(12) into its active cofactor forms, and to deliver it to two known B(12-)dependent enzymes. Herein, we report an unexpected strategy for cellular retention of B(12), an essential and reactive cofactor. If methylm...

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Udgivet i:J Am Chem Soc
Main Authors: Campanello, Gregory C., Ruetz, Markus, Dodge, Greg J., Gouda, Harsha, Gupta, Aditi, Twahir, Umar T., Killian, Michelle M., Watkins, David, Rosenblatt, David S., Brunold, Thomas C., Warncke, Kurt, Smith, Janet L., Banerjee, Ruma
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6743335/
https://ncbi.nlm.nih.gov/pubmed/30282455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b08659
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