Sacrificial Cobalt−Carbon Bond Homolysis in Coenzyme B(12) as a Cofactor Conservation Strategy

A sophisticated intracellular trafficking pathway in humans is used to tailor vitamin B(12) into its active cofactor forms, and to deliver it to two known B(12-)dependent enzymes. Herein, we report an unexpected strategy for cellular retention of B(12), an essential and reactive cofactor. If methylm...

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Détails bibliographiques
Publié dans:J Am Chem Soc
Auteurs principaux: Campanello, Gregory C., Ruetz, Markus, Dodge, Greg J., Gouda, Harsha, Gupta, Aditi, Twahir, Umar T., Killian, Michelle M., Watkins, David, Rosenblatt, David S., Brunold, Thomas C., Warncke, Kurt, Smith, Janet L., Banerjee, Ruma
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6743335/
https://ncbi.nlm.nih.gov/pubmed/30282455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b08659
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