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Mobile loop dynamics in adenosyltransferase control binding and reactivity of coenzyme B(12)

Cobalamin is a complex organometallic cofactor that is processed and targeted via a network of chaperones to its dependent enzymes. AdoCbl (5′-deoxyadenosylcobalamin) is synthesized from cob(II)alamin in a reductive adenosylation reaction catalyzed by adenosyltransferase (ATR), which also serves as...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Mascarenhas, Romila, Ruetz, Markus, McDevitt, Liam, Koutmos, Markos, Banerjee, Ruma
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7720225/
https://ncbi.nlm.nih.gov/pubmed/33199623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2007332117
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