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Autoinhibition and Signaling by the Switch II Motif in the G-protein Chaperone of a Radical B(12) Enzyme
MeaB is an accessory GTPase protein involved in the assembly, protection, and reactivation of 5′-deoxyadenosyl cobalamin-dependent methylmalonyl-CoA mutase (MCM). Mutations in the human ortholog of MeaB result in methylmalonic aciduria, an inborn error of metabolism. G-proteins typically utilize con...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3829411/ https://ncbi.nlm.nih.gov/pubmed/23996001 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.499970 |
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