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Loss of Allostery and Coenzyme B(12) Delivery by a Pathogenic Mutation in Adenosyltransferase
ATP-dependent cob(I)alamin adenosyltransferase (ATR) is a bifunctional protein; an enzyme that catalyzes the adenosylation of cob(I)alamin and an escort that delivers the product, adenosylcobalamin (AdoCbl or coenzyme B(12)), to methylmalonyl-CoA mutase (MCM), resulting in holoenzyme formation. Fail...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3119721/ https://ncbi.nlm.nih.gov/pubmed/21604717 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2006306 |
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