Sacrificial Cobalt−Carbon Bond Homolysis in Coenzyme B(12) as a Cofactor Conservation Strategy

A sophisticated intracellular trafficking pathway in humans is used to tailor vitamin B(12) into its active cofactor forms, and to deliver it to two known B(12-)dependent enzymes. Herein, we report an unexpected strategy for cellular retention of B(12), an essential and reactive cofactor. If methylm...

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Bibliografiska uppgifter
I publikationen:J Am Chem Soc
Huvudupphovsmän: Campanello, Gregory C., Ruetz, Markus, Dodge, Greg J., Gouda, Harsha, Gupta, Aditi, Twahir, Umar T., Killian, Michelle M., Watkins, David, Rosenblatt, David S., Brunold, Thomas C., Warncke, Kurt, Smith, Janet L., Banerjee, Ruma
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6743335/
https://ncbi.nlm.nih.gov/pubmed/30282455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b08659
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