cAMP- and cGMP-elevating agents inhibit GPIbα-mediated aggregation but not GPIbα-stimulated Syk activation in human platelets

BACKGROUND: The glycoprotein (GP) Ib-IX-V complex is a unique platelet plasma membrane receptor, which is essential for platelet adhesion and thrombus formation. GPIbα, part of the GPIb-IX-V complex, has several physiological ligands such as von Willebrand factor (vWF), thrombospondin and distinct c...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cell Commun Signal
Auteurs principaux: Makhoul, Stephanie, Trabold, Katharina, Gambaryan, Stepan, Tenzer, Stefan, Pillitteri, Daniele, Walter, Ulrich, Jurk, Kerstin
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2019
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6743169/
https://ncbi.nlm.nih.gov/pubmed/31519182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-019-0428-1
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