Differential roles of cAMP and cGMP in megakaryocyte maturation and platelet biogenesis

The cyclic nucleotides cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) regulate the activity of protein kinase A (PKA) and protein kinase G (PKG), respectively. This process helps maintain circulating platelets in a resting state. Here we studied the role of cAMP and...

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Autores principales: Begonja, Antonija Jurak, Gambaryan, Stepan, Schulze, Harald, Patel-Hett, Sunita, Italiano, Joseph E., Hartwig, John H., Walter, Ulrich
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3638753/
https://ncbi.nlm.nih.gov/pubmed/22981933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2012.09.001
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