cAMP- and cGMP-elevating agents inhibit GPIbα-mediated aggregation but not GPIbα-stimulated Syk activation in human platelets

BACKGROUND: The glycoprotein (GP) Ib-IX-V complex is a unique platelet plasma membrane receptor, which is essential for platelet adhesion and thrombus formation. GPIbα, part of the GPIb-IX-V complex, has several physiological ligands such as von Willebrand factor (vWF), thrombospondin and distinct c...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:Cell Commun Signal
Glavni autori: Makhoul, Stephanie, Trabold, Katharina, Gambaryan, Stepan, Tenzer, Stefan, Pillitteri, Daniele, Walter, Ulrich, Jurk, Kerstin
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2019
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6743169/
https://ncbi.nlm.nih.gov/pubmed/31519182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-019-0428-1
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items