Therapeutic efficacy of a novel humanized antibody-drug conjugate recognizing plexin-semaphorin-integrin domain in the RON receptor for targeted cancer therapy

BACKGROUND: Antibody-drug conjugates (ADCs) targeting the RON receptor, a tumorigenic factor contributing to cancer malignancy, has been considered as a novel strategy for cancer therapy. Here we describe a humanized antibody recognizing the RON plexin-semaphorin-integrin (PSI) domain with increased...

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Publicado no:J Immunother Cancer
Main Authors: Tong, Xiang-Min, Feng, Liang, Suthe, Sreedhar Reddy, Weng, Tian-Hao, Hu, Chen-Yu, Liu, Yi-Zhi, Wu, Zhi-Gang, Wang, Ming-Hai, Yao, Hang-Ping
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6743155/
https://ncbi.nlm.nih.gov/pubmed/31519211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0732-8
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