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Pathogenic hantaviruses bind plexin–semaphorin–integrin domains present at the apex of inactive, bent αvβ3 integrin conformers
The αvβ3 integrins are linked to human bleeding disorders, and pathogenic hantaviruses regulate the function of αvβ3 integrins and cause acute vascular diseases. αvβ3 integrins are present in either extended (active) or dramatically bent (inactive) structures, and interconversion of αvβ3 conformers...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2005
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC545842/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15657120/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0406743102 |
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