Therapeutic efficacy, pharmacokinetic profiles, and toxicological activities of humanized antibody-drug conjugate Zt/g4-MMAE targeting RON receptor tyrosine kinase for cancer therapy

BACKGROUND: Aberrant expression of the RON receptor tyrosine kinase is a pathogenic feature and a validated drug target in various types of cancers. Currently, therapeutic antibodies targeting RON for cancer therapy are under intensive evaluation. Here we report the development and validation of a n...

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Bibliographic Details
Published in:J Immunother Cancer
Main Authors: Yao, Hang-Ping, Feng, Liang, Suthe, Sreedhar Reddy, Chen, Ling-Hui, Weng, Tian-Hao, Hu, Chen-Yu, Jun, Eun Sung, Wu, Zhi-Gang, Wang, Wei-Lin, Kim, Song Cheol, Tong, Xiang-Min, Wang, Ming-Hai
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6419354/
https://ncbi.nlm.nih.gov/pubmed/30871619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0525-0
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