Developmental Regulation of the Proteolysis of the p35 Cyclin-Dependent Kinase 5 Activator by Phosphorylation

Cyclin-dependent kinase 5 (Cdk5), a cdc2-related kinase expressed in postmitotic neurons, is activated by association with a brain-specific activator, p35. It has been suggested that the conversion of p35 to p25 by the protease calpain is involved in neuronal cell death. However, p35 protein is turn...

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Publicado no:J Neurosci
Main Authors: Saito, Taro, Onuki, Reiko, Fujita, Yuichi, Kusakawa, Gen-ichi, Ishiguro, Koichi, Bibb, James A., Kishimoto, Takeo, Hisanaga, Shin-ichi
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2003
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6742280/
https://ncbi.nlm.nih.gov/pubmed/12598607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-04-01189.2003
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