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De novo MET amplification promotes intrinsic resistance to first-generation EGFR tyrosine kinase inhibitors

First-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) could induce dramatic tumor responses in non-small-cell lung cancer patients with EGFR-activating mutations. However, a small proportion of patients have no tumor response on initial EGFR TKI treatment with an...

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Bibliografische gegevens
Gepubliceerd in:Cancer Biol Ther
Hoofdauteurs: Li, Jing-Wen, Cao, Shu-Hui, Xu, Jian-Lin, Zhong, Hua
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis 2019
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6741769/
https://ncbi.nlm.nih.gov/pubmed/31131689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2019.1617568
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