Upregulation of Sodium Channel Na(v)1.3 and Functional Involvement in Neuronal Hyperexcitability Associated with Central Neuropathic Pain after Spinal Cord Injury

Spinal cord injury (SCI) can result in hyperexcitability of dorsal horn neurons and central neuropathic pain. We hypothesized that these phenomena are consequences, in part, of dysregulated expression of voltage-gated sodium channels. Because the rapidly repriming TTX-sensitive sodium channel Na(v)1...

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Pubblicato in:J Neurosci
Autori principali: Hains, Bryan C., Klein, Joshua P., Saab, Carl Y., Craner, Matthew J., Black, Joel A., Waxman, Stephen G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2003
Soggetti:
Development/Plasticity/Repair
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6740400/
https://ncbi.nlm.nih.gov/pubmed/14523090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-26-08881.2003
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