KDM2B in polycomb repressive complex 1.1 functions as a tumor suppressor in the initiation of T-cell leukemogenesis

KDM2B together with RING1B, PCGF1, and BCOR or BCORL1 comprise polycomb repressive complex 1.1 (PRC1.1), a noncanonical PRC1 that catalyzes H2AK119ub1. It binds to nonmethylated CpG islands through its zinc finger-CxxC DNA binding domain and recruits the complex to target gene loci. Recent studies i...

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Vydáno v:Blood Adv
Hlavní autoři: Isshiki, Yusuke, Nakajima-Takagi, Yaeko, Oshima, Motohiko, Aoyama, Kazumasa, Rizk, Mohamed, Kurosawa, Shuhei, Saraya, Atsunori, Kondo, Takashi, Sakaida, Emiko, Nakaseko, Chiaki, Yokote, Koutaro, Koseki, Haruhiko, Iwama, Atsushi
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2019
Témata:
Lymphoid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6737409/
https://ncbi.nlm.nih.gov/pubmed/31471323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018028522
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