Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation by the CMG Helicase of the Eukaryotic Replisome

In the eukaryotic replisome, DNA unwinding by the Cdc45-MCM-Go-Ichi-Ni-San (GINS) (CMG) helicase requires a hexameric ring-shaped ATPase named minichromosome maintenance (MCM), which spools single-stranded DNA through its central channel. Not all six ATPase sites are required for unwinding; however,...

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Bibliographic Details
Published in:Cell Rep
Main Authors: Eickhoff, Patrik, Kose, Hazal B., Martino, Fabrizio, Petojevic, Tatjana, Abid Ali, Ferdos, Locke, Julia, Tamberg, Nele, Nans, Andrea, Berger, James M., Botchan, Michael R., Yardimci, Hasan, Costa, Alessandro
Format: Artigo
Language:Inglês
Published: Cell Press 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6737378/
https://ncbi.nlm.nih.gov/pubmed/31484077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.07.104
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