Cdc45 (cell division cycle protein 45) guards the gate of the Eukaryote Replisome helicase stabilizing leading strand engagement

DNA replication licensing is now understood to be the pathway that leads to the assembly of double hexamers of minichromosome maintenance (Mcm2–7) at origin sites. Cell division control protein 45 (Cdc45) and GINS proteins activate the latent Mcm2–7 helicase by inducing allosteric changes through bi...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Petojevic, Tatjana, Pesavento, James J., Costa, Alessandro, Liang, Jingdan, Wang, Zhijun, Berger, James M., Botchan, Michael R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2015
Ämnen:
PNAS Plus
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4311868/
https://ncbi.nlm.nih.gov/pubmed/25561522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1422003112
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