DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome

The Cdc45/Mcm2-7/GINS (CMG) helicase separates DNA strands during replication in eukaryotes. How the CMG is assembled and engages DNA substrates remains unclear. Using electron microscopy, we have determined the structure of the CMG in the presence of ATPγS and a DNA duplex bearing a 3′ single-stran...

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Bibliografische gegevens
Gepubliceerd in:eLife
Hoofdauteurs: Costa, Alessandro, Renault, Ludovic, Swuec, Paolo, Petojevic, Tatjana, Pesavento, James J, Ilves, Ivar, MacLellan-Gibson, Kirsty, Fleck, Roland A, Botchan, Michael R, Berger, James M
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: eLife Sciences Publications, Ltd 2014
Onderwerpen:
Biochemistry
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359367/
https://ncbi.nlm.nih.gov/pubmed/25117490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.03273
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