DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome

The Cdc45/Mcm2-7/GINS (CMG) helicase separates DNA strands during replication in eukaryotes. How the CMG is assembled and engages DNA substrates remains unclear. Using electron microscopy, we have determined the structure of the CMG in the presence of ATPγS and a DNA duplex bearing a 3′ single-stran...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:eLife
Hlavní autoři: Costa, Alessandro, Renault, Ludovic, Swuec, Paolo, Petojevic, Tatjana, Pesavento, James J, Ilves, Ivar, MacLellan-Gibson, Kirsty, Fleck, Roland A, Botchan, Michael R, Berger, James M
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2014
Témata:
Biochemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359367/
https://ncbi.nlm.nih.gov/pubmed/25117490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.03273
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky