Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome

Eukaryotic origin firing depends on assembly of the Cdc45-MCM-GINS (CMG) helicase. A key step is the recruitment of GINS that requires the leading-strand polymerase Pol epsilon, composed of Pol2, Dpb2, Dpb3, Dpb4. While a truncation of the catalytic N-terminal Pol2 supports cell division, Dpb2 and C...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Goswami, Panchali, Abid Ali, Ferdos, Douglas, Max E., Locke, Julia, Purkiss, Andrew, Janska, Agnieszka, Eickhoff, Patrik, Early, Anne, Nans, Andrea, Cheung, Alan M. C., Diffley, John F. X., Costa, Alessandro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6265327/
https://ncbi.nlm.nih.gov/pubmed/30498216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07417-1
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