Mechanisms of aggregation and fibril formation of the amyloidogenic N-terminal fragment of apolipoprotein A-I

The N-terminal (1–83) fragment of the major constituent of plasma high-density lipoprotein, apolipoprotein A-I (apoA-I), strongly tends to form amyloid fibrils, leading to systemic amyloidosis. Here, using a series of deletion variants, we examined the roles of two major amyloidogenic segments (resi...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Mizuguchi, Chiharu, Nakagawa, Miho, Namba, Norihiro, Sakai, Misae, Kurimitsu, Naoko, Suzuki, Ayane, Fujita, Kaho, Horiuchi, Sayaka, Baba, Teruhiko, Ohgita, Takashi, Nishitsuji, Kazuchika, Saito, Hiroyuki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6737231/
https://ncbi.nlm.nih.gov/pubmed/31341020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008000
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