Effect of Phosphatidylserine and Cholesterol on Membrane-mediated Fibril Formation by the N-terminal Amyloidogenic Fragment of Apolipoprotein A-I

Here, we examined the effects of phosphatidylserine (PS) and cholesterol on the fibril-forming properties of the N-terminal 1‒83 fragment of an amyloidogenic G26R variant of apoA-I bound to small unilamellar vesicles. A thioflavin T fluorescence assay together with microscopic observations showed th...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Mizuguchi, Chiharu, Nakamura, Mitsuki, Kurimitsu, Naoko, Ohgita, Takashi, Nishitsuji, Kazuchika, Baba, Teruhiko, Shigenaga, Akira, Shimanouchi, Toshinori, Okuhira, Keiichiro, Otaka, Akira, Saito, Hiroyuki
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5882889/
https://ncbi.nlm.nih.gov/pubmed/29615818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-23920-3
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