Cellular Interaction and Cytotoxicity of the Iowa Mutation of Apolipoprotein A-I (ApoA-I(Iowa)) Amyloid Mediated by Sulfate Moieties of Heparan Sulfate

The single amino acid mutation G26R in human apolipoprotein A-I (apoA-I) is associated with familial amyloid polyneuropathy III. ApoA-I carrying this mutation (apoA-I(Iowa)) forms amyloid fibrils in vitro. Heparan sulfate (HS) is a glycosaminoglycan that is abundant at the cell surface and in the ex...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:J Biol Chem
Main Authors: Kuwabara, Kaori, Nishitsuji, Kazuchika, Uchimura, Kenji, Hung, Shang-Cheng, Mizuguchi, Makoto, Nakajima, Hiroyuki, Mikawa, Shiho, Kobayashi, Norihiro, Saito, Hiroyuki, Sakashita, Naomi
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2015
נושאים:
Glycobiology and Extracellular Matrices
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591809/
https://ncbi.nlm.nih.gov/pubmed/26292220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.652545
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