Cellular Interaction and Cytotoxicity of the Iowa Mutation of Apolipoprotein A-I (ApoA-I(Iowa)) Amyloid Mediated by Sulfate Moieties of Heparan Sulfate

The single amino acid mutation G26R in human apolipoprotein A-I (apoA-I) is associated with familial amyloid polyneuropathy III. ApoA-I carrying this mutation (apoA-I(Iowa)) forms amyloid fibrils in vitro. Heparan sulfate (HS) is a glycosaminoglycan that is abundant at the cell surface and in the ex...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Kuwabara, Kaori, Nishitsuji, Kazuchika, Uchimura, Kenji, Hung, Shang-Cheng, Mizuguchi, Makoto, Nakajima, Hiroyuki, Mikawa, Shiho, Kobayashi, Norihiro, Saito, Hiroyuki, Sakashita, Naomi
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
Glycobiology and Extracellular Matrices
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591809/
https://ncbi.nlm.nih.gov/pubmed/26292220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.652545
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