Myeloperoxidase-mediated Methionine Oxidation Promotes an Amyloidogenic Outcome for Apolipoprotein A-I

High plasma levels of apolipoprotein A-I (apoA-I) correlate with cardiovascular health, whereas dysfunctional apoA-I is a cause of atherosclerosis. In the atherosclerotic plaques, amyloid deposition increases with aging. Notably, apoA-I is the main component of these amyloids. Recent studies identif...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Chan, Gary K. L., Witkowski, Andrzej, Gantz, Donald L., Zhang, Tianqi O., Zanni, Martin T., Jayaraman, Shobini, Cavigiolio, Giorgio
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2015
Soggetti:
Protein Structure and Folding
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409257/
https://ncbi.nlm.nih.gov/pubmed/25759391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.630442
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