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Oxidation of methionine residues in human apolipoprotein A-I generates a potent pro-inflammatory molecule

Amyloid deposits of apolipoprotein A-I (apoA-I) and inflammation are common in atherosclerotic arteries. In this study, we investigated the interplay between oxidation of apoA-I methionine residues (Met(O)-ApoA-I), a known amyloidogenic modification of apoA-I, and the inflammatory response of immune...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Witkowski, Andrzej, Carta, Sonia, Lu, Rui, Yokoyama, Shinji, Rubartelli, Anna, Cavigiolio, Giorgio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6416445/
https://ncbi.nlm.nih.gov/pubmed/30635405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005663
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