Methionine oxidation impairs reverse cholesterol transport by apolipoprotein A-I

HDL protects against vascular disease by accepting free cholesterol from macrophage foam cells in the artery wall. This pathway is critically dependent on lecithin:cholesterol acyltransferase (LCAT), which rapidly converts cholesterol to cholesteryl ester. The physiological activator of LCAT is apol...

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Hlavní autoři: Shao, Baohai, Cavigiolio, Giorgio, Brot, Nathan, Oda, Michael N., Heinecke, Jay W.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2008
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527893/
https://ncbi.nlm.nih.gov/pubmed/18719109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802025105
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