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Oxidation of apolipoprotein A-I by myeloperoxidase impairs the initial interactions with ABCA1 required for signaling and cholesterol export1

A key cardioprotective effect of high-density lipoprotein involves the interaction of its major protein, apolipoprotein A-I (apoA-I) with ATP-binding cassette transporter A1 (ABCA1), a macrophage cholesterol exporter. ApoA-I is thought to remove cholesterol from macrophages by a cascade of events. F...

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Main Authors: Shao, Baohai, Tang, Chongren, Heinecke, Jay W., Oram, John F.
格式: Artigo
語言:Inglês
出版: The American Society for Biochemistry and Molecular Biology 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882738/
https://ncbi.nlm.nih.gov/pubmed/20064972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M004085
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