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Site-specific Oxidation of Apolipoprotein A-I Impairs Cholesterol Export by ABCA1, a Key Cardioprotective Function of HDL
The mechanisms that deprive HDL of its cardioprotective properties are poorly understood. One potential pathway involves oxidative damage of HDL proteins by myeloperoxidase (MPO) a heme enzyme secreted by human artery wall macrophages. Mass spectrometric analysis demonstrated that levels of 3-chloro...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3288272/ https://ncbi.nlm.nih.gov/pubmed/22178192 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2011.11.011 |
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