De novo synthesis of serine and glycine fuels purine nucleotide biosynthesis in human lung cancer tissues

Nucleotide synthesis is essential to proliferating cells, but the preferred precursors for de novo biosynthesis are not defined in human cancer tissues. We have employed multiplexed stable isotope-resolved metabolomics to track the metabolism of [(13)C(6)]glucose, D(2)-glycine, [(13)C(2)]glycine, an...

Full description

Saved in:
Bibliographic Details
Published in:J Biol Chem
Main Authors: Fan, Teresa W. M., Bruntz, Ronald C., Yang, Ye, Song, Huan, Chernyavskaya, Yelena, Deng, Pan, Zhang, Yan, Shah, Parag P., Beverly, Levi J., Qi, Zhen, Mahan, Angela L., Higashi, Richard M., Dang, Chi V., Lane, Andrew N.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2019
Subjects:
Metabolism
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6737211/
https://ncbi.nlm.nih.gov/pubmed/31337706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008743
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items