De novo synthesis of serine and glycine fuels purine nucleotide biosynthesis in human lung cancer tissues

Nucleotide synthesis is essential to proliferating cells, but the preferred precursors for de novo biosynthesis are not defined in human cancer tissues. We have employed multiplexed stable isotope-resolved metabolomics to track the metabolism of [(13)C(6)]glucose, D(2)-glycine, [(13)C(2)]glycine, an...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Fan, Teresa W. M., Bruntz, Ronald C., Yang, Ye, Song, Huan, Chernyavskaya, Yelena, Deng, Pan, Zhang, Yan, Shah, Parag P., Beverly, Levi J., Qi, Zhen, Mahan, Angela L., Higashi, Richard M., Dang, Chi V., Lane, Andrew N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2019
Schlagworte:
Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6737211/
https://ncbi.nlm.nih.gov/pubmed/31337706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008743
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