De novo synthesis of serine and glycine fuels purine nucleotide biosynthesis in human lung cancer tissues

Nucleotide synthesis is essential to proliferating cells, but the preferred precursors for de novo biosynthesis are not defined in human cancer tissues. We have employed multiplexed stable isotope-resolved metabolomics to track the metabolism of [(13)C(6)]glucose, D(2)-glycine, [(13)C(2)]glycine, an...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Fan, Teresa W. M., Bruntz, Ronald C., Yang, Ye, Song, Huan, Chernyavskaya, Yelena, Deng, Pan, Zhang, Yan, Shah, Parag P., Beverly, Levi J., Qi, Zhen, Mahan, Angela L., Higashi, Richard M., Dang, Chi V., Lane, Andrew N.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2019
Onderwerpen:
Metabolism
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6737211/
https://ncbi.nlm.nih.gov/pubmed/31337706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008743
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