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RuvC uses dynamic probing of the Holliday junction to achieve sequence specificity and efficient resolution

Holliday junctions (HJs) are four-way DNA structures that occur in DNA repair by homologous recombination. Specialized nucleases, termed resolvases, remove (i.e., resolve) HJs. The bacterial protein RuvC is a canonical resolvase that introduces two symmetric cuts into the HJ. For complete resolution...

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Библиографические подробности
Опубликовано в: :Nat Commun
Главные авторы: Górecka, Karolina Maria, Krepl, Miroslav, Szlachcic, Aleksandra, Poznański, Jarosław, Šponer, Jiří, Nowotny, Marcin
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2019
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6736871/
https://ncbi.nlm.nih.gov/pubmed/31506434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11900-8
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