RNA exploits an exposed regulatory site to inhibit the enzymatic activity of PRC2

Polycomb repressive complex 2 (PRC2) is a histone methyltransferase that maintains cell identity during development in multicellular organisms by marking repressed genes and chromatin domains. In addition to four core subunits, PRC2 comprises multiple accessory subunits that vary in their compositio...

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Détails bibliographiques
Publié dans:Nat Struct Mol Biol
Auteurs principaux: Zhang, Qi, McKenzie, Nicholas J., Warneford-Thomson, Robert, Gail, Emma H., Flanigan, Sarena F., Owen, Brady M., Lauman, Richard, Levina, Vitalina, Garcia, Benjamin A., Schittenhelm, Ralf B., Bonasio, Roberto, Davidovich, Chen
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6736635/
https://ncbi.nlm.nih.gov/pubmed/30833789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-019-0197-y
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