RNA exploits an exposed regulatory site to inhibit the enzymatic activity of PRC2

Polycomb repressive complex 2 (PRC2) is a histone methyltransferase that maintains cell identity during development in multicellular organisms by marking repressed genes and chromatin domains. In addition to four core subunits, PRC2 comprises multiple accessory subunits that vary in their compositio...

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Udgivet i:Nat Struct Mol Biol
Main Authors: Zhang, Qi, McKenzie, Nicholas J., Warneford-Thomson, Robert, Gail, Emma H., Flanigan, Sarena F., Owen, Brady M., Lauman, Richard, Levina, Vitalina, Garcia, Benjamin A., Schittenhelm, Ralf B., Bonasio, Roberto, Davidovich, Chen
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6736635/
https://ncbi.nlm.nih.gov/pubmed/30833789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-019-0197-y
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