RNA exploits an exposed regulatory site to inhibit the enzymatic activity of PRC2

Polycomb repressive complex 2 (PRC2) is a histone methyltransferase that maintains cell identity during development in multicellular organisms by marking repressed genes and chromatin domains. In addition to four core subunits, PRC2 comprises multiple accessory subunits that vary in their compositio...

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Pubblicato in:Nat Struct Mol Biol
Autori principali: Zhang, Qi, McKenzie, Nicholas J., Warneford-Thomson, Robert, Gail, Emma H., Flanigan, Sarena F., Owen, Brady M., Lauman, Richard, Levina, Vitalina, Garcia, Benjamin A., Schittenhelm, Ralf B., Bonasio, Roberto, Davidovich, Chen
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6736635/
https://ncbi.nlm.nih.gov/pubmed/30833789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-019-0197-y
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