RNA exploits an exposed regulatory site to inhibit the enzymatic activity of PRC2

Polycomb repressive complex 2 (PRC2) is a histone methyltransferase that maintains cell identity during development in multicellular organisms by marking repressed genes and chromatin domains. In addition to four core subunits, PRC2 comprises multiple accessory subunits that vary in their compositio...

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Publicado en:Nat Struct Mol Biol
Main Authors: Zhang, Qi, McKenzie, Nicholas J., Warneford-Thomson, Robert, Gail, Emma H., Flanigan, Sarena F., Owen, Brady M., Lauman, Richard, Levina, Vitalina, Garcia, Benjamin A., Schittenhelm, Ralf B., Bonasio, Roberto, Davidovich, Chen
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6736635/
https://ncbi.nlm.nih.gov/pubmed/30833789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-019-0197-y
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