RNA exploits an exposed regulatory site to inhibit the enzymatic activity of PRC2

Polycomb repressive complex 2 (PRC2) is a histone methyltransferase that maintains cell identity during development in multicellular organisms by marking repressed genes and chromatin domains. In addition to four core subunits, PRC2 comprises multiple accessory subunits that vary in their compositio...

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Dades bibliogràfiques
Publicat a:Nat Struct Mol Biol
Autors principals: Zhang, Qi, McKenzie, Nicholas J., Warneford-Thomson, Robert, Gail, Emma H., Flanigan, Sarena F., Owen, Brady M., Lauman, Richard, Levina, Vitalina, Garcia, Benjamin A., Schittenhelm, Ralf B., Bonasio, Roberto, Davidovich, Chen
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6736635/
https://ncbi.nlm.nih.gov/pubmed/30833789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-019-0197-y
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