The glucocorticoid receptor DNA-binding domain recognizes RNA hairpin structures with high affinity

The glucocorticoid receptor (GR) binds the noncoding RNA Gas5 via its DNA-binding domain (DBD) with functional implications in pro-apoptosis signaling. Here, we report a comprehensive in vitro binding study where we have determined that GR-DBD is a robust structure-specific RNA-binding domain. GR-DB...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Parsonnet, Nicholas V, Lammer, Nickolaus C, Holmes, Zachariah E, Batey, Robert T, Wuttke, Deborah S
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
RNA and RNA-protein complexes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6735959/
https://ncbi.nlm.nih.gov/pubmed/31147715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz486
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