The role of ZAP and OAS3/RNAseL pathways in the attenuation of an RNA virus with elevated frequencies of CpG and UpA dinucleotides

Zinc finger antiviral protein (ZAP) is a powerful restriction factor for viruses with elevated CpG dinucleotide frequencies. We report that ZAP similarly mediates antiviral restriction against echovirus 7 (E7) mutants with elevated frequencies of UpA dinucleotides. Attenuation of both CpG- and UpA-h...

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Bibliografische gegevens
Gepubliceerd in:Nucleic Acids Res
Hoofdauteurs: Odon, Valerie, Fros, Jelke J, Goonawardane, Niluka, Dietrich, Isabelle, Ibrahim, Ahmad, Alshaikhahmed, Kinda, Nguyen, Dung, Simmonds, Peter
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2019
Onderwerpen:
Molecular Biology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6735852/
https://ncbi.nlm.nih.gov/pubmed/31276592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz581
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