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CpG and UpA dinucleotides in both coding and non-coding regions of echovirus 7 inhibit replication initiation post-entry

Most vertebrate and plant RNA and small DNA viruses suppress genomic CpG and UpA dinucleotide frequencies, apparently mimicking host mRNA composition. Artificially increasing CpG/UpA dinucleotides attenuates viruses through an entirely unknown mechanism. Using the echovirus 7 (E7) model in several c...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:eLife
Egile Nagusiak: Fros, Jelke Jan, Dietrich, Isabelle, Alshaikhahmed, Kinda, Passchier, Tim Casper, Evans, David John, Simmonds, Peter
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: eLife Sciences Publications, Ltd 2017
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659819/
https://ncbi.nlm.nih.gov/pubmed/28960178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.29112
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