Massively parallel profiling and predictive modeling of the outcomes of CRISPR/Cas9-mediated double-strand break repair

Non-homologous end-joining (NHEJ) plays an important role in double-strand break (DSB) repair of DNA. Recent studies have shown that the error patterns of NHEJ are strongly biased by sequence context, but these studies were based on relatively few templates. To investigate this more thoroughly, we s...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nucleic Acids Res
Egile Nagusiak: Chen, Wei, McKenna, Aaron, Schreiber, Jacob, Haeussler, Maximilian, Yin, Yi, Agarwal, Vikram, Noble, William Stafford, Shendure, Jay
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2019
Gaiak:
Genome Integrity, Repair and Replication
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6735782/
https://ncbi.nlm.nih.gov/pubmed/31165867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz487
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