Alborixin clears amyloid-β by inducing autophagy through PTEN-mediated inhibition of the AKT pathway

Imbalance in production and clearance of amyloid beta (Aβ) is the primary reason for its deposition in Alzheimer disease. Macroautophagy/autophagy is one of the important mechanisms for clearance of both intracellular and extracellular Aβ. Here, through screening, we identified alborixin, an ionopho...

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Bibliografski detalji
Izdano u:Autophagy
Glavni autori: Wani, Abubakar, Gupta, Mehak, Ahmad, Masroor, Shah, Aabid M., Ahsan, Aitizaz Ul, Qazi, Parvaiz H, Malik, Fayaz, Singh, Gurdarshan, Sharma, Parduman R., Kaddoumi, Amal, Bharate, Sandip B., Vishwakarma, Ram A., Kumar, Ajay
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2019
Teme:
Research Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6735498/
https://ncbi.nlm.nih.gov/pubmed/30894052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1596476
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