IIIM-941, a Stilbene Derivative Inhibits NLRP3 Inflammasome Activation by Inducing Autophagy

Aberrant activation of NLRP3 inflammasome has been implicated in several inflammatory diseases. Autophagy is one of the primary mechanisms that regulate NLRP3 inflammasome activity. In this study, we attempted to target NLRP3 inflammasome activity by a synthetic compound IIIM-941. We found that IIIM...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Ali, Mehboob, Gupta, Mehak, Wani, Abubakar, Sharma, Ankita, Abdullaha, Mohd, Kour, Dilpreet, Choudhary, Sushil, Bharate, Sandip B., Singh, Gurdarshan, Kumar, Ajay
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8267097/
https://ncbi.nlm.nih.gov/pubmed/34248643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.695712
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