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Selection of a Water-Soluble Salt Form of a Preclinical Candidate, IIIM-290: Multiwell-Plate Salt Screening and Characterization
[Image: see text] IIIM-290, a semisynthetic derivative of natural product rohitukine, is an orally bioavailable Cdk inhibitor, efficacious in the xenograft models of colon, pancreatic, and leukemia cancer. Its low aqueous solubility (∼8.6 μg/mL) could be one of the reasons for achieving optimal in v...
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| Publicado en: | ACS Omega |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Chemical Society
2018
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| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6072253/ https://ncbi.nlm.nih.gov/pubmed/30087943 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.8b00801 |
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