IIIM-941, a Stilbene Derivative Inhibits NLRP3 Inflammasome Activation by Inducing Autophagy

Aberrant activation of NLRP3 inflammasome has been implicated in several inflammatory diseases. Autophagy is one of the primary mechanisms that regulate NLRP3 inflammasome activity. In this study, we attempted to target NLRP3 inflammasome activity by a synthetic compound IIIM-941. We found that IIIM...

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Detalles Bibliográficos
Publicado en:Front Pharmacol
Autores principales: Ali, Mehboob, Gupta, Mehak, Wani, Abubakar, Sharma, Ankita, Abdullaha, Mohd, Kour, Dilpreet, Choudhary, Sushil, Bharate, Sandip B., Singh, Gurdarshan, Kumar, Ajay
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8267097/
https://ncbi.nlm.nih.gov/pubmed/34248643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.695712
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