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Potential role of LSD1 inhibitors in the treatment of sickle cell disease: a review of preclinical animal model data
Sickle cell disease (SCD) is caused by a mutation of the β-globin gene (Ingram VM. Nature 180: 326–328, 1957), which triggers the polymerization of deoxygenated sickle hemoglobin (HbS). Approximately 100,000 SCD patients in the United States and millions worldwide (Piel FB, et al. PLoS Med 10: e1001...
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| Veröffentlicht in: | Am J Physiol Regul Integr Comp Physiol |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Physiological Society
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6734057/ https://ncbi.nlm.nih.gov/pubmed/30067082 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00440.2017 |
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