Pharmacological inhibition of LSD1 and mTOR reduces mitochondrial retention and associated ROS levels in the red blood cells of sickle cell disease

Sickle cell disease (SCD), an inherited blood disorder caused by a point mutation that renders hemoglobin susceptible to polymerization when deoxygenated, affects millions of people worldwide. Manifestations of SCD include chronic hemolytic anemia, inflammation, painful vaso-occlusive crises, multis...

Full description

Saved in:
Bibliographic Details
Published in:Exp Hematol
Main Authors: Jagadeeswaran, Ramasamy, Vazquez, Benjamin A., Thiruppathi, Muthusamy, Ganesh, Balaji B., Ibanez, Vinzon, Cui, Shuaiying, Engel, James D., Diamond, Alan M., Molokie, Robert E., DeSimone, Joseph, Lavelle, Donald, Rivers., Angela
Format: Artigo
Language:Inglês
Published: 2017
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6263958/
https://ncbi.nlm.nih.gov/pubmed/28238805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2017.02.003
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items