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Spatial oxidation of L-plastin downmodulates actin-based functions of tumor cells
Several antitumor therapies work by increasing reactive oxygen species (ROS) within the tumor micromilieu. Here, we reveal that L-plastin (LPL), an established tumor marker, is reversibly regulated by ROS-induced thiol oxidation on Cys101, which forms a disulfide bridge with Cys42. LPL reduction is...
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| Publicat a: | Nat Commun |
|---|---|
| Autors principals: | , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6733871/ https://ncbi.nlm.nih.gov/pubmed/31501427 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11909-z |
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