Spatial oxidation of L-plastin downmodulates actin-based functions of tumor cells

Several antitumor therapies work by increasing reactive oxygen species (ROS) within the tumor micromilieu. Here, we reveal that L-plastin (LPL), an established tumor marker, is reversibly regulated by ROS-induced thiol oxidation on Cys101, which forms a disulfide bridge with Cys42. LPL reduction is...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Balta, Emre, Hardt, Robert, Liang, Jie, Kirchgessner, Henning, Orlik, Christian, Jahraus, Beate, Hillmer, Stefan, Meuer, Stefan, Hübner, Katrin, Wabnitz, Guido H., Samstag, Yvonne
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6733871/
https://ncbi.nlm.nih.gov/pubmed/31501427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11909-z
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