Spatial oxidation of L-plastin downmodulates actin-based functions of tumor cells

Several antitumor therapies work by increasing reactive oxygen species (ROS) within the tumor micromilieu. Here, we reveal that L-plastin (LPL), an established tumor marker, is reversibly regulated by ROS-induced thiol oxidation on Cys101, which forms a disulfide bridge with Cys42. LPL reduction is...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Balta, Emre, Hardt, Robert, Liang, Jie, Kirchgessner, Henning, Orlik, Christian, Jahraus, Beate, Hillmer, Stefan, Meuer, Stefan, Hübner, Katrin, Wabnitz, Guido H., Samstag, Yvonne
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6733871/
https://ncbi.nlm.nih.gov/pubmed/31501427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11909-z
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados