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Excitotoxic neurodegeneration is associated with a focal decrease in metabotropic glutamate receptor type 5 availability: an in vivo PET imaging study

Metabotropic glutamate receptors (mGluRs) have been proposed as promising therapeutic targets to correct the dysregulated glutamate signaling, associated with neurodegenerative pathologies. Of all mGluR subtypes, especially mGluR5 acts as a modulator of glutamate-induced excitotoxicity. To study the...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Crabbé, Melissa, Dirkx, Nina, Casteels, Cindy, Laere, Koen Van
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6733799/
https://ncbi.nlm.nih.gov/pubmed/31501497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-49356-x
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